Oral pseudomembranous candidiasis, herpes simplex virus‐1 infection, and oral mucositis in head and neck cancer patients receiving radiotherapy and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) mouthwash
Identifieur interne : 004602 ( Istex/Curation ); précédent : 004601; suivant : 004603Oral pseudomembranous candidiasis, herpes simplex virus‐1 infection, and oral mucositis in head and neck cancer patients receiving radiotherapy and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) mouthwash
Auteurs : Ourania Nicolatou-Galitis [Grèce] ; Konstantinos Dardoufas [Grèce] ; Panagiotis Markoulatos [Grèce] ; Anastasia Sotiropoulou-Lontou [Grèce] ; Konstantinos Kyprianou [Grèce] ; Georgia Kolitsi [Grèce] ; George Pissakas [Grèce] ; Christos Skarleas [Grèce] ; Vassilis Kouloulias [Grèce] ; Vassilis Papanicolaou ; Nicolaos J. Legakis [Grèce] ; Aristea Velegraki [Grèce]Source :
- Journal of Oral Pathology & Medicine [ 0904-2512 ] ; 2001-09.
English descriptors
- KwdEn :
- Albicans, Antifungal, Antimycotic treatment, Antiviral, Antiviral treatment, Candida, Candida albicans, Candida species, Candidal, Candidiasis, Carcinoma, Chemotherapy, Concomitant, Concomitant chemotherapy, Herpes, Last week, Lesion, Local control, Mouthwash, Mucosal, Mucosal ulcers, Mucositis, Mucositis grade, Mucositis grades, Nasopharyngeal carcinoma, Neck cancer patients, Neck radiotherapy, Oncol, Oral candidiasis, Oral cavity, Oral lesions, Oral mucosa, Oral mucositis, Oral pathol, Oral pathology, Oral pseudomembranous candidiasis, Oral surg, Pathol, Polymerase chain reaction, Preplanned time, Present study, Pseudomembranous, Pseudomembranous candidiasis, Radiat oncol biol phys, Radiation mucositis, Radiation therapy, Radiotherapy, Reactivation, Same patient, Simplex, Surg, Total dose, Ulcer, Ulceration, Viral culture.
- Teeft :
- Albicans, Antifungal, Antimycotic treatment, Antiviral, Antiviral treatment, Candida, Candida albicans, Candida species, Candidal, Candidiasis, Carcinoma, Chemotherapy, Concomitant, Concomitant chemotherapy, Herpes, Last week, Lesion, Local control, Mouthwash, Mucosal, Mucosal ulcers, Mucositis, Mucositis grade, Mucositis grades, Nasopharyngeal carcinoma, Neck cancer patients, Neck radiotherapy, Oncol, Oral candidiasis, Oral cavity, Oral lesions, Oral mucosa, Oral mucositis, Oral pathol, Oral pathology, Oral pseudomembranous candidiasis, Oral surg, Pathol, Polymerase chain reaction, Preplanned time, Present study, Pseudomembranous, Pseudomembranous candidiasis, Radiat oncol biol phys, Radiation mucositis, Radiation therapy, Radiotherapy, Reactivation, Same patient, Simplex, Surg, Total dose, Ulcer, Ulceration, Viral culture.
Abstract
Abstract: Oral pseudomembranous candidiasis (OPC) was evaluated in 61 patients receiving head and neck radiotherapy (RT). Herpes simplex virus‐1 (HSV‐1) reactivation was also investigated in 14 patients. According to the agreed protocol, granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) mouthwash was administered in 46 patients with radiation‐induced ulcers. Candidiasis was diagnosed in 31 patients. Candida albicans was the most frequent isolate. Multiple Candida species were isolated from the lesions of four patients. Concurrent candidiasis and radiation‐induced ulcers were observed in 17 patients. Viral culture and the polymerase chain reaction disclosed the presence of HSV‐1 in five patients. Twenty of the 46 patients, with initial mucositis grade II and grade III, completed RT with mucositis grade I, indicating a beneficial effect of GM‐CSF mouthwash, although further controlled studies are necessary to verify that. In conclusion, OPC was an important infection in patients undergoing radiotherapy. The role of HSV‐1 in oral mucositis during head and neck radiotherapy needs additional study.
Url:
DOI: 10.1034/j.1600-0714.2001.030008471.x
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Ourania Nicolatou-Galitis<affiliation><mods:affiliation>E-mail: nicolatou.galitis@mailcity.com</mods:affiliation><wicri:noCountry code="no comma">E-mail: nicolatou.galitis@mailcity.com</wicri:noCountry></affiliation><affiliation><mods:affiliation>General Hospital of Kalamata, Kalamata and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oral pseudomembranous candidiasis, herpes simplex virus‐1 infection, and oral mucositis in head and neck cancer patients receiving radiotherapy and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) mouthwash</title><author><name sortKey="Nicolatou Alitis, Ourania" sort="Nicolatou Alitis, Ourania" uniqKey="Nicolatou Alitis O" first="Ourania" last="Nicolatou-Galitis">Ourania Nicolatou-Galitis</name><affiliation wicri:level="3"><mods:affiliation>Department of Oral Pathology and Surgery, School of Dentistry, University of Athens, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Department of Oral Pathology and Surgery, School of Dentistry, University of Athens</wicri:orgArea></affiliation><affiliation><mods:affiliation>E-mail: nicolatou.galitis@mailcity.com</mods:affiliation><wicri:noCountry code="no comma">E-mail: nicolatou.galitis@mailcity.com</wicri:noCountry></affiliation></author><author><name sortKey="Dardoufas, Konstantinos" sort="Dardoufas, Konstantinos" uniqKey="Dardoufas K" first="Konstantinos" last="Dardoufas">Konstantinos Dardoufas</name><affiliation wicri:level="3"><mods:affiliation>Radiation Department, School of Medicine, “Aretaieio” Hospital, University of Athens, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Radiation Department, School of Medicine, “Aretaieio” Hospital, University of Athens</wicri:orgArea></affiliation></author><author><name sortKey="Markoulatos, Panagiotis" sort="Markoulatos, Panagiotis" uniqKey="Markoulatos P" first="Panagiotis" last="Markoulatos">Panagiotis Markoulatos</name><affiliation wicri:level="3"><mods:affiliation>Greek Institute of Pasteur, Department of Virology, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Greek Institute of Pasteur, Department of Virology</wicri:orgArea></affiliation></author><author><name sortKey="Sotiropoulou Ontou, Anastasia" sort="Sotiropoulou Ontou, Anastasia" uniqKey="Sotiropoulou Ontou A" first="Anastasia" last="Sotiropoulou-Lontou">Anastasia Sotiropoulou-Lontou</name><affiliation wicri:level="3"><mods:affiliation>Second Radiation Department, “O Aghios Savas” Hospital, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Second Radiation Department, “O Aghios Savas” Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Kyprianou, Konstantinos" sort="Kyprianou, Konstantinos" uniqKey="Kyprianou K" first="Konstantinos" last="Kyprianou">Konstantinos Kyprianou</name><affiliation wicri:level="3"><mods:affiliation>Radiation Department, “Hygeia” Hospital, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Radiation Department, “Hygeia” Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Kolitsi, Georgia" sort="Kolitsi, Georgia" uniqKey="Kolitsi G" first="Georgia" last="Kolitsi">Georgia Kolitsi</name><affiliation wicri:level="3"><mods:affiliation>Radiation Department, “Hygeia” Hospital, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Radiation Department, “Hygeia” Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Pissakas, George" sort="Pissakas, George" uniqKey="Pissakas G" first="George" last="Pissakas">George Pissakas</name><affiliation wicri:level="3"><mods:affiliation>Second Radiation Department, “O Aghios Savas” Hospital, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Second Radiation Department, “O Aghios Savas” Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Skarleas, Christos" sort="Skarleas, Christos" uniqKey="Skarleas C" first="Christos" last="Skarleas">Christos Skarleas</name><affiliation wicri:level="3"><mods:affiliation>Radiation Department, School of Medicine, “Aretaieio” Hospital, University of Athens, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Radiation Department, School of Medicine, “Aretaieio” Hospital, University of Athens</wicri:orgArea></affiliation></author><author><name sortKey="Kouloulias, Vassilis" sort="Kouloulias, Vassilis" uniqKey="Kouloulias V" first="Vassilis" last="Kouloulias">Vassilis Kouloulias</name><affiliation wicri:level="3"><mods:affiliation>Radiation Department, School of Medicine, “Aretaieio” Hospital, University of Athens, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Radiation Department, School of Medicine, “Aretaieio” Hospital, University of Athens</wicri:orgArea></affiliation></author><author><name sortKey="Papanicolaou, Vassilis" sort="Papanicolaou, Vassilis" uniqKey="Papanicolaou V" first="Vassilis" last="Papanicolaou">Vassilis Papanicolaou</name><affiliation><mods:affiliation>General Hospital of Kalamata, Kalamata and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Legakis, Nicolaos J" sort="Legakis, Nicolaos J" uniqKey="Legakis N" first="Nicolaos J." last="Legakis">Nicolaos J. Legakis</name><affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Mycology Reference Laboratory, School of Medicine, University of Athens, Athens, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Microbiology, Mycology Reference Laboratory, School of Medicine, University of Athens, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Velegraki, Aristea" sort="Velegraki, Aristea" uniqKey="Velegraki A" first="Aristea" last="Velegraki">Aristea Velegraki</name><affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Mycology Reference Laboratory, School of Medicine, University of Athens, Athens, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Microbiology, Mycology Reference Laboratory, School of Medicine, University of Athens, Athens</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8C7E0A949B857CE0988B7E96C926AB0BFCCBE92C</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1034/j.1600-0714.2001.030008471.x</idno><idno type="url">https://api.istex.fr/document/8C7E0A949B857CE0988B7E96C926AB0BFCCBE92C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">004602</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">004602</idno><idno type="wicri:Area/Istex/Curation">004602</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Oral pseudomembranous candidiasis, herpes simplex virus‐1 infection, and oral mucositis in head and neck cancer patients receiving radiotherapy and granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) mouthwash</title><author><name sortKey="Nicolatou Alitis, Ourania" sort="Nicolatou Alitis, Ourania" uniqKey="Nicolatou Alitis O" first="Ourania" last="Nicolatou-Galitis">Ourania Nicolatou-Galitis</name><affiliation wicri:level="3"><mods:affiliation>Department of Oral Pathology and Surgery, School of Dentistry, University of Athens, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Department of Oral Pathology and Surgery, School of Dentistry, University of Athens</wicri:orgArea></affiliation><affiliation><mods:affiliation>E-mail: nicolatou.galitis@mailcity.com</mods:affiliation><wicri:noCountry code="no comma">E-mail: nicolatou.galitis@mailcity.com</wicri:noCountry></affiliation></author><author><name sortKey="Dardoufas, Konstantinos" sort="Dardoufas, Konstantinos" uniqKey="Dardoufas K" first="Konstantinos" last="Dardoufas">Konstantinos Dardoufas</name><affiliation wicri:level="3"><mods:affiliation>Radiation Department, School of Medicine, “Aretaieio” Hospital, University of Athens, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Radiation Department, School of Medicine, “Aretaieio” Hospital, University of Athens</wicri:orgArea></affiliation></author><author><name sortKey="Markoulatos, Panagiotis" sort="Markoulatos, Panagiotis" uniqKey="Markoulatos P" first="Panagiotis" last="Markoulatos">Panagiotis Markoulatos</name><affiliation wicri:level="3"><mods:affiliation>Greek Institute of Pasteur, Department of Virology, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Greek Institute of Pasteur, Department of Virology</wicri:orgArea></affiliation></author><author><name sortKey="Sotiropoulou Ontou, Anastasia" sort="Sotiropoulou Ontou, Anastasia" uniqKey="Sotiropoulou Ontou A" first="Anastasia" last="Sotiropoulou-Lontou">Anastasia Sotiropoulou-Lontou</name><affiliation wicri:level="3"><mods:affiliation>Second Radiation Department, “O Aghios Savas” Hospital, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Second Radiation Department, “O Aghios Savas” Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Kyprianou, Konstantinos" sort="Kyprianou, Konstantinos" uniqKey="Kyprianou K" first="Konstantinos" last="Kyprianou">Konstantinos Kyprianou</name><affiliation wicri:level="3"><mods:affiliation>Radiation Department, “Hygeia” Hospital, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Radiation Department, “Hygeia” Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Kolitsi, Georgia" sort="Kolitsi, Georgia" uniqKey="Kolitsi G" first="Georgia" last="Kolitsi">Georgia Kolitsi</name><affiliation wicri:level="3"><mods:affiliation>Radiation Department, “Hygeia” Hospital, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Radiation Department, “Hygeia” Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Pissakas, George" sort="Pissakas, George" uniqKey="Pissakas G" first="George" last="Pissakas">George Pissakas</name><affiliation wicri:level="3"><mods:affiliation>Second Radiation Department, “O Aghios Savas” Hospital, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Second Radiation Department, “O Aghios Savas” Hospital</wicri:orgArea></affiliation></author><author><name sortKey="Skarleas, Christos" sort="Skarleas, Christos" uniqKey="Skarleas C" first="Christos" last="Skarleas">Christos Skarleas</name><affiliation wicri:level="3"><mods:affiliation>Radiation Department, School of Medicine, “Aretaieio” Hospital, University of Athens, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Radiation Department, School of Medicine, “Aretaieio” Hospital, University of Athens</wicri:orgArea></affiliation></author><author><name sortKey="Kouloulias, Vassilis" sort="Kouloulias, Vassilis" uniqKey="Kouloulias V" first="Vassilis" last="Kouloulias">Vassilis Kouloulias</name><affiliation wicri:level="3"><mods:affiliation>Radiation Department, School of Medicine, “Aretaieio” Hospital, University of Athens, Athens</mods:affiliation><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName><wicri:orgArea>Radiation Department, School of Medicine, “Aretaieio” Hospital, University of Athens</wicri:orgArea></affiliation></author><author><name sortKey="Papanicolaou, Vassilis" sort="Papanicolaou, Vassilis" uniqKey="Papanicolaou V" first="Vassilis" last="Papanicolaou">Vassilis Papanicolaou</name><affiliation><mods:affiliation>General Hospital of Kalamata, Kalamata and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Legakis, Nicolaos J" sort="Legakis, Nicolaos J" uniqKey="Legakis N" first="Nicolaos J." last="Legakis">Nicolaos J. Legakis</name><affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Mycology Reference Laboratory, School of Medicine, University of Athens, Athens, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Microbiology, Mycology Reference Laboratory, School of Medicine, University of Athens, Athens</wicri:regionArea></affiliation></author><author><name sortKey="Velegraki, Aristea" sort="Velegraki, Aristea" uniqKey="Velegraki A" first="Aristea" last="Velegraki">Aristea Velegraki</name><affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Mycology Reference Laboratory, School of Medicine, University of Athens, Athens, Greece</mods:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Microbiology, Mycology Reference Laboratory, School of Medicine, University of Athens, Athens</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Oral Pathology & Medicine</title><title level="j" type="alt">JOURNAL ORAL PATHOLOGY MEDICINE</title><idno type="ISSN">0904-2512</idno><idno type="eISSN">1600-0714</idno><imprint><biblScope unit="vol">30</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="471">471</biblScope><biblScope unit="page" to="480">480</biblScope><biblScope unit="page-count">10</biblScope><publisher>Munksgaard International Publishers</publisher><pubPlace>Copenhagen</pubPlace><date type="published" when="2001-09">2001-09</date></imprint><idno type="ISSN">0904-2512</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0904-2512</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Albicans</term><term>Antifungal</term><term>Antimycotic treatment</term><term>Antiviral</term><term>Antiviral treatment</term><term>Candida</term><term>Candida albicans</term><term>Candida species</term><term>Candidal</term><term>Candidiasis</term><term>Carcinoma</term><term>Chemotherapy</term><term>Concomitant</term><term>Concomitant chemotherapy</term><term>Herpes</term><term>Last week</term><term>Lesion</term><term>Local control</term><term>Mouthwash</term><term>Mucosal</term><term>Mucosal ulcers</term><term>Mucositis</term><term>Mucositis grade</term><term>Mucositis grades</term><term>Nasopharyngeal carcinoma</term><term>Neck cancer patients</term><term>Neck radiotherapy</term><term>Oncol</term><term>Oral candidiasis</term><term>Oral cavity</term><term>Oral lesions</term><term>Oral mucosa</term><term>Oral mucositis</term><term>Oral pathol</term><term>Oral pathology</term><term>Oral pseudomembranous candidiasis</term><term>Oral surg</term><term>Pathol</term><term>Polymerase chain reaction</term><term>Preplanned time</term><term>Present study</term><term>Pseudomembranous</term><term>Pseudomembranous candidiasis</term><term>Radiat oncol biol phys</term><term>Radiation mucositis</term><term>Radiation therapy</term><term>Radiotherapy</term><term>Reactivation</term><term>Same patient</term><term>Simplex</term><term>Surg</term><term>Total dose</term><term>Ulcer</term><term>Ulceration</term><term>Viral culture</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Albicans</term><term>Antifungal</term><term>Antimycotic treatment</term><term>Antiviral</term><term>Antiviral treatment</term><term>Candida</term><term>Candida albicans</term><term>Candida species</term><term>Candidal</term><term>Candidiasis</term><term>Carcinoma</term><term>Chemotherapy</term><term>Concomitant</term><term>Concomitant chemotherapy</term><term>Herpes</term><term>Last week</term><term>Lesion</term><term>Local control</term><term>Mouthwash</term><term>Mucosal</term><term>Mucosal ulcers</term><term>Mucositis</term><term>Mucositis grade</term><term>Mucositis grades</term><term>Nasopharyngeal carcinoma</term><term>Neck cancer patients</term><term>Neck radiotherapy</term><term>Oncol</term><term>Oral candidiasis</term><term>Oral cavity</term><term>Oral lesions</term><term>Oral mucosa</term><term>Oral mucositis</term><term>Oral pathol</term><term>Oral pathology</term><term>Oral pseudomembranous candidiasis</term><term>Oral surg</term><term>Pathol</term><term>Polymerase chain reaction</term><term>Preplanned time</term><term>Present study</term><term>Pseudomembranous</term><term>Pseudomembranous candidiasis</term><term>Radiat oncol biol phys</term><term>Radiation mucositis</term><term>Radiation therapy</term><term>Radiotherapy</term><term>Reactivation</term><term>Same patient</term><term>Simplex</term><term>Surg</term><term>Total dose</term><term>Ulcer</term><term>Ulceration</term><term>Viral culture</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Abstract: Oral pseudomembranous candidiasis (OPC) was evaluated in 61 patients receiving head and neck radiotherapy (RT). Herpes simplex virus‐1 (HSV‐1) reactivation was also investigated in 14 patients. According to the agreed protocol, granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) mouthwash was administered in 46 patients with radiation‐induced ulcers. Candidiasis was diagnosed in 31 patients. Candida albicans was the most frequent isolate. Multiple Candida species were isolated from the lesions of four patients. Concurrent candidiasis and radiation‐induced ulcers were observed in 17 patients. Viral culture and the polymerase chain reaction disclosed the presence of HSV‐1 in five patients. Twenty of the 46 patients, with initial mucositis grade II and grade III, completed RT with mucositis grade I, indicating a beneficial effect of GM‐CSF mouthwash, although further controlled studies are necessary to verify that. In conclusion, OPC was an important infection in patients undergoing radiotherapy. The role of HSV‐1 in oral mucositis during head and neck radiotherapy needs additional study.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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